Laboratory of Experimental Nuclear Medicine A. Tsyb MRRC

Tishchenko Viktoria Konstantinovna

POSITION: Head of the Experimental Nuclear Medicine Laboratory at the A. Tsyb MRRC – a branch of the FSBI ‘National Medical Research Radiological Centre’ of the Ministry of Health of Russian Federation
ACADEMIC DEGREE: Doctor of Biological Sciences
MAIN AREAS OF SCIENTIFIC ACTIVITY: Development of radiochemical synthesis technologies for innovative radiopharmaceutical drugs for radionuclide diagnostics and therapy of oncological diseases.

Radio-chemical Synthesis of Radiopharmaceuticals Group
Biological Research of Radiopharmaceuticals Group
EPR Dosimetry Group

Senior Researcher, PhD in Physics and Mathematics: Ivanikov Alexander Ivanovich
Senior Researcher, PhD in Biology: Vlasova Oksana Petrovna
Senior Researcher, PhD in Biology: Belkina Svetlana Vladimirovna
Leading Researcher, PhD in Biology: Khailov Artem Mikhailovich
Leading Researcher, PhD in Biology: Lebedeva Anastasia Alexandrovna Researcher
Orlenko Sergey Pavlovich Researcher: Chibisova Olga Fedorovna
Junior Researcher: Stepchenkova Ekaterina Dmitrievna
Junior Researcher: Fedorova Alena Vladimirovna
Lead Engineer: Demidova Nadezhda Alexeevna
Lead Engineer: Ryzhikova Tamara Pavlovna
Lead Engineer: Fetisova Tatyana Vladimirovna
Engineer 1st Class: Petriev Vitaliy Vasilievich
Engineer 1st Class: Tishchenko Vasily Vasilievich
Engineer 2nd Class: Ostroukhov Alexander Antonovich
Engineer: Shcherbakova Anastasia Nikolaevna
Engineer: Dorovatovsky Stanislav Anatolievich
Engineer: Golomazov Alexander Mikhailovich
Engineer: Magomedov Gazimagomed Yusupovich
Engineer: Zaborskaya Kristina Andreevna
Laboratory Assistant: Zhukova Alexandra Vasilievna
Laboratory Assistant: Stepanova Lyudmila Nikolaevna
Laboratory Assistant: Alexandrova Maya Igorevna

Development of technologies for the radiochemical synthesis of radiopharmaceutical therapeutic agents.
Biological studies on the functional suitability and safety of radiopharmaceutical therapeutic agents.
Development of technologies for producing lyophilisates – substances for producing radiopharmaceutical therapeutic agents.
Development of laboratory and pilot-industrial protocols for the production of lyophilisates and radiopharmaceutical therapeutic agents.
Creation of experimental and pilot samples of lyophilisates and radiopharmaceutical therapeutic agents.
Conducting preclinical studies of radiopharmaceutical therapeutic agents.
Assessment of individual radiation doses using samples of calcined biological tissues (tooth enamel and dentine, bone) as well as nail samples. This method is used for retrospective evaluation of the degree of uncontrolled radiation exposure in radiation accidents.
Assessment of radiation doses in human organs and dosimetric material samples under exposure to various types of ionising radiation (gamma, beta, neutrons) during emergency, laboratory and therapeutic irradiation.

Radiopharmaceutical for the treatment of primary hepatocellular carcinoma and metastatic liver lesions, as well as its composition and method of preparation. Dorvatovsky S.A., Petriev V.M., Zverev A.V., Skvortsov V.G., Galkin V.N., Kaprin A.D. Patent RU 2698111 dated 22.08.2019, priority 09.10.2017.
Radiopharmaceutical composition for the treatment of inflammatory joint diseases based on radionuclide 188Re and human blood albumin microspheres, as well as its composition and method of preparation. Zverev A.V., Dorvatovsky S.A., Petriev V.M., Skvortsov V.G., Kaprin A.D., Antonyuk A.V., Laskovets E.Yu. Patent RU 2698101 dated 22.08.2019, priority 25.05.2018.
Device for positron emission tomography. Postnov A.A., Petriev V.M., Zavestovskaya I.N., Stepanova T.V. Utility model patent RU 196435 U1, 28.02.2020, priority 30.12.2019.
Method for producing radionuclide-labelled microspheres. Kaprin A.D., Ivanov S.A., Petriev V.M., Vlasova O.P., Ryzhikova T.P., Nerozin N.A., Shapovalov V.V., Stepchenkov D.V., Sulim E.V. Patent RU 2724880 dated 26.06.2020, priority 16.10.2019.

Complex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals. Petriev V. M., Tishchenko V. K., Smoryzanova O. A., Zavestovskaya I. N., Postnov A. A. Bulletin of the Lebedev Physics Institute. 2019. V. 46, No. 5. P. 58–64
Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy. Petriev V.M., Tischenko V.K., Mikhailovskaya A.A., Popov A.A., Tselikov G., Zelepukin I., Deyev S.M., Kaprin A.D., Ivanov S., Timoshenko V.Yu., Prasad P.N., Zavestovskaya I.N., Kabashin A.V. Scientific Reports. 2019. V. 9, No. 2017. P. 1-10.
Biodistribution ex vivo of 213Bi-KHEDP – a promising boneseeking agent for targeted alpha therapy. Tishchenko V.K., Petriev V.M., Stepchenkova E.D., Zavestovskaya I.N., Ivanov S.A., Kaprin A.D. IOP Conf. Series: Journal of Physics. Conf. Series 1189. 2019.No. 012034
Biological evaluation of histidine and tryptophan labeled with gallium-68 as potential tumor imaging agents. Tishchenko V.K.,Petriev V.M., Mikhailovskaya A.A., Kuzenkova K.A., Kaprin A.D., Ivanov S.A., Zavestovskaya I.N. IOP Conf. Series: Journal of Physics. Conf. Series 1189. 2019. No. 012038
The biodistribution of a new bone-seeking agent based on pentaphosphonic acid and gallium-68 in tumor-bearing rats. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Smoryzanova O.A., Postnov A.A. IOP Conf. Series: Journal of Physics. Conf. Series 1189. 2019. No. 012042
The influence of carrier addition on the biodistribution of bone-seeking agent «188Re-oxa-bis(ethylenenitrilo)- tetramethylenephosphonic acid». Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Smoryzanova O.S., Kuzenkova K.A. IOP Conf. Series: Journal of Physics. Conf. Series 1189. 2019. No. 012044
Фармакокинетические свойства и противоопухолевая эффективность нового радиофармпрепарата на основе 153Sm в термочувствительном носителе на опухолевой модели гепатохолангиомы РС-1. Петриев В.М., Тищенко В.К.,Сморызанова О.А., Михайловская А.А., Больбит Н.М., Дуфлот В.Р., Морозова Н.Б., Якубовская Р.И. Радиация и риск. 2019. Т. 28, № 2. С. 124-133
Effect of Gallium Carrier in 68Ga-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals.Petriev V.M., Tishchenko V.K., Stepchenkova E.D., Zavestovskaya I.N., Shegai P.V., Ivanov S.A., Karpin A.D. Bulletin of the Lebedev Physics Institute. 2019. V. 46, No. 10. P. 319-323
Фармакокинетические свойства нового остеотропного соединения на основе N,N,N’N’-этилендиаминтетракис(метиленфосфоновой кислоты), меченной 68Ga, у интактных крыс и крыс с экспериментальной моделью костной мозоли. Тищенко В.К., Петриев В.М., Михайловская А.А., Сморызанова О.А., Иванов С.А., Каприн А.Д. Радиация и Риск. 2019. Т. 28, № 4. С. 108-117
Advanced technologies of nuclear medicine and radiotherapy. Zavestovskaya I.N., Kabashin A.V., Petriev V.M., Postnov A.A. Сборник тезисов 3 Международной научно-практической конференции «Радиофарма-2019». 2019. С. 8
Иттрий-90 для радиоэмболизации неоперабельных опухолей печени. Болонкин А.С., Власова О.П., Клементьева О.Е., Кузнецов А.А., Нерозин Н.А., Петриев В.М., Семенова А.А., Степченков Д.В., Сулим Е.В., Ткачев С.В., Тогаева Н.Р., Шаповалов В.В. Сборник тезисов 3 Международной научно-практической конференции «Радиофарма-2019». 2019. С. 49
Pharmacokinetic properties of a new potential tumor imaging agent based on glucose derivative and gallium-68. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Stepchenkova E.D., Zavestovskaya I.N. 4th International Symposium and School for Young Scientists on “Physics, Engineering and Technologies for Biomedicine”, Book of Abstracts, October 26-30, 2019, P. 62-63
The influence of temperature on biodistribution of N,N,N’,N’-ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Kuzenkova K.A., Zavestovskaya I.N. 4th International Symposium and School for Young Scientists on “Physics, Engineering and Technologies for Biomedicine”, Book of Abstracts, October 26–30, 2019, P. 206–208.
Сравнительное изучение биораспределения новых остеотропных соединений на основе фосфоновых кислот и галлия-68. Тищенко В.К., Петриев В.М., Кузенкова К.А., Степченкова Е.Д., Шегай П.В. Материалы Второго Международного Форума онкологии и радиологии, Москва, 23–27 сентября 2019 г. Исследования и практика в медицине. 2019. Т. 6, Спецвыпуск 1, С. 267
The influence of temperature on biodistribution of N,N,N’,N’-ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Kuzenkova K.A., Zavestovskaya I.N. 4th International Symposium and School for Young Scientists on “Physics, Engineering and Technologies for Biomedicine”, Book of Abstracts, October 26–30. 2019. P. 206–208
Сравнительное изучение биораспределения новых остеотропных соединений на основе фосфоновых кислот и галлия-68. Тищенко В.К., Петриев В.М., Кузенкова К.А., Степченкова Е.Д., Шегай П.В. Материалы Второго Международного Форума онкологии и радиологии, Москва, 23–27 сентября 2019 г. Исследования и практика в медицине. 2019. Т. 6, Спецвыпуск 1. С. 267
Изучение влияния 68Ga на накопление и флуоресценцию Фоторана Е6 на модели экспериментальных лабораторных мышей C57Bl/6 с перевитой подкожно меланомой B16 (The study of the effects of 68GA on accumulation and fluorescence of photoran E6 on the model of experimental C57BL/6 laboratory mice with melanoma B16. Береговская Е.А, Чурикова Т.П., Абрамова О.Б., Тищенко В.К., Петриев В.М. (Beregovskaya E.A., Churikova T.P., Abramova O.B., Tishchenko V.K., Petriev V.M.) // Международная молодежная конференция «Современные проблемы радиобиологии, радиоэкологии и агроэкологии (International Youth Conference Topic issues of radiobiology, radioecology and agroecology), Обнинск, 3-4 октября 2019 г. С. 24-25
The influence of chemical structure of phosphonic acids labeled with gallium-68 on their pharmacokinetic properties in animals.Petriev V.V., Tishchenko V.K., Mikhailovskaya A.A., Stepchenkova E.D., Kuzenkova K.A., Postnov A.A., Zavestovskaya I.N. Journal of Physics: Conference Series. 2020. V. 1439, No. 1. P. 012031
Preliminary biological evaluation of 99mTc-glucosamine as a potential radiotracer for tumor imaging. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Smoryzanova O.A., Ivanov C.A., Kaprin A.D. Journal of Physics: Conference Series. 2020. V. 1439, No. 1. P. 012033
Ex vivo biodistribution of gallium-68-labeled porous silicon nanoparticles. Tishchenko V.K., Petriev V.M., Mikhailovskaya A.A., Smoryzanova O.A., Kabashin K.A., Zavestovskaya I.N. Journal of Physics: Conference Series. 2020. V. 1439, No. 1. P. 012035
Biodistribution of 68Ga-DTPMP as a potential bone-seeking imaging agent in normal rats and rats with experimental model of bone callus. Tishchenko V.K., Petriev V.M., Stepchenkova E.D., Fedorova A.V., Postnov A.A., Zavestovskaya I.N. Journal of Physics: Conference Series. 2020. V. 1439, No. 1. P. 012039
Остеотропные радиофармацевтические препараты на основе фосфоновых кислот и галлия-68 (Обзор). Тищенко В.К.,Петриев В.М., Завестовская И.Н., Иванов С.А., Каприн А.Д. Радиация и риск. 2020. Т. 29, № 1. С. 102-113
Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68.Tishchenko V.K., Petriev V.M., Stepchenkova E.D., Timoshenko V.Yu., Postnov A.A., Zavestovskaya I.N. Bulletin of Experimental Biology and Medicine. 2020. V. 168, No. 6. P. 777-780
Behavior of Gallium-68 Incorporated in NODA Aminoglucose in Laboratory Animals with Various Pathological Processes.Tishchenko V.K., Petriev V.M., Fedorova A.V., Ekatova T.Yu., Zavestovskaya I.N. Bulletin of the Lebedev Physics Institute. 2020. V. 47, № 7. P. 213-217
Биораспределение 68Ga-NODA-аминоглюкозы в организме интактных мышей и мышей-опухоленосителей.
A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus. Tishchenko V.K., Petriev V.M., Kuzenkova K.A., Shegai P.V., Ivanov S.A., Kaprin A.D. Bulletin of Experimental Biology and Medicine. 2020. V. 169, № 5. P. 644-647
Особенности поведения радионуклида галлия-68 в составе производных глюкозы в организме лабораторных животных. Петриев В.М., Тищенко В.К., Степченкова Е.Д., Федоров О.В., Фроня А.А. Краткие сообщения по физике ФИАН. 2020. T. 47, № 7. С. 19-27
Behavioral Features of Gallium-68 Radionuclide Incorporated in Glucose Derivatives in Laboratory Animals. Petriev V.M., Tishchenko V.K., Stepchenkova E.D., Fedorov O.V, Fronya A.A. Bulletin of the Lebedev Physics Institute. 2020. V. 47, № 11. P. 339-344
Результаты доклинических исследований безопасности радиофармпрепарата с 90 y для внутриартериальной радиоэмболизации злокачественных новообразований печени. Медицинская радиология и радиационная безопасность Клементьева О.Е., Власова О.П., Степченков Д.В., Лунёва К.А., Терновская К.Э., Петриев В.М., Степченкова Е.Д., Кузнецов А.А., Артамонов С.А., Мурашин К.А., Шегай П.В., Иванов С.А., Каприн А.Д. 2020. Т. 65, № 5. С. 51–59
Результаты доклинических испытаний эффективности радиофармпрепарата «ДТПА-микросферы альбумина, 90 Y».Власова О.П., Степченкова Е.Д., Петриев В.М., Клементьева О.Е., Степченков Д.В., Красноперова А.С., Кузнецов А.А., Нерозин Н.А., Иванов С.А., Каприн А.Д. Медицинская радиология и радиационная безопасность. 2020. Т. 65, № 5. С. 60–67
Machine learning for determination of the native background EPR signal amplitude in the teeth enamel. Khailov A., Ivannikov A., Zhumadilov K., Stepanenko V., Kaprin A., Shegay P., Ivanov S. Radiation Measurements. 2020. V. 137. P/ 106435.
Formation of different types of paramagnetic centers in the alanine dosimeters exposed to alpha and gamma radiation – study by EPR spectroscopy. Ivannikov A., Khailov A., Orlenko S., Stepanenko V., Trompier F., Zhumadilov K. Radiation Measurements. 2020. V. 137. P. 106467
ESR tooth enamel retrospective dosimetry quoted as spin numbers. Toyoda S., Murahashi M., Ivannikov A. Radiation Measurements. 2020. V. 132. P. 106333