Department of Radiation and Surgical Treatment of Urologic Diseases with Prostate Cancer Brachytherapy Group

Oleg Borisovich Karyakin

POSITION: Head of the Department of Radiotherapy and Surgical Treatment of Urological Diseases with a Prostate Cancer Brachytherapy Group at the A. Tsyb MRRC – a branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of Health of Russian Federation
ACADEMIC DEGREE: Doctor of Medical Sciences, Professor, Honoured Scientist of the Russian Federation
SCIENTIFIC ACTIVITY: development, improvement and advancement of methods for combined comprehensive treatment of oncological urological diseases, enhancement of endoscopic surgery techniques in the combined treatment of genitourinary system tumours, development and implementation of various irradiation sources for prostate cancer, study of the effectiveness of drug therapy in the combined treatment of genitourinary system tumours.

Safiullin Kadir Nazipovich, Leading Researcher, Doctor of Medical Sciences
Biryukov Vitaliy Alexandrovich, Senior Researcher, Candidate of Medical Sciences
Obukhov Alexander Alexandrovich, Oncologist, Candidate of Medical Sciences
Chaikov Vladimir Sergeevich, Researcher
Zaborsky Ivan Nikolaevich, Researcher
Troyanov Alexey Vladimirovich, Oncologist
Dementyev Ivan Olegovich, Junior Researcher

Development and implementation of new methods for combined treatment of patients with kidney, bladder, and prostate cancer.
Study of the effectiveness of methods for evaluating efficiency and predicting disease progression in the process of combined and comprehensive treatment.
Development of methods for organ-preserving treatment of bladder cancer.
Development of new methods for combined treatment of prostate cancer based on brachytherapy with other types of drug and radiation therapy.

Method of interstitial, high-dose brachytherapy for locally advanced pelvic tumours with lateral invasion into the pelvic wall. Kaprin A.D., Ivanov S.A., Kostyuk I.P., Goulidov I.A., Korotkov V.A., Birbkov V.A., Borysheva N.B., Vasiliev L.A., Rukhadze G.O., Sokolov P.V. Patent No. 2719935 dated 16.08.2019
Method of comprehensive hormone-chemoradiation therapy for localized or locally advanced prostate cancer with high and very high risk of progression. Troyanov A.V., Karyakin O.B., Biryukov V.A., Gumenetskaya Y.V. Patent No. 2716942 dated 30.08.2019

Smith M, Parker C, Saad F, Miller K, Tombal B, Ng QS, Boegemann M, Matveev V, Piulats JM, Zucca LE, Karyakin O, Kimura G, Matsubara N, Nahas WC, Nole F, Rosenbaum E, Heidenreich, Kakehi Y, Zhang A, Krissel H, Teufel M, Shen J, Wagner V, Higano C. Addition of radium-223 to abiraterone acetate and prednisone or prednisolone in patients with castration-resistant prostate cancer and bone metastases (ERA 223): a randomised, double-blind, placebo-controled, phase 3 trial. //Lancet Oncol. 2019. 20. P. 408-419.
Korenevsky N.A., Seregin S.P., Karyakin O.B., Biryukov V.A., Dolzhenkov S.D., Dmitrieva V.V. Hardware-software complex for assessing the health status and treatment efficacy of the prostate. //Medical Technology. 2019. No. 1. Pp. 41-43.
Makarova K.S., Gumenetskaya Yu.V., Biryukov V.A., Obukhov A.A., Strikanova I.A., Dzhabrailova S.O., Lepilina O.G., Borysheva N.B., Karyakin O.B., Ivanov S.A., Kaprin A.D. Combined radiation therapy in patients with high-risk prostate cancer. Analysis of treatment complications. //Siberian Journal of Oncology. 2019. No. 18 (2). Pp. 15-21.
Zaborsky I.N., Ivanov S.A., Mushkarina T.Yu., Karyakin O.B., Kuzmina E.G., Safiullin K.N., Chaikov V.S., Troyanov A.V., Dementyev I.O., Kasymov M.R., Demyashkin G.A. Study of the relationships between the expression of molecular markers in tumour and immunocompetent cells with sensitivity to adjuvant and neoadjuvant therapy of bladder cancer. //Oncourology. Moscow. 2019. Vol. 15, No. 2. Pp. 100-106.
Karyakin O.B., Kaprin A.D., Ivanov S.A. National registry of systemic therapy for patients with metastatic castration-resistant prostate cancer. //Oncourology. Moscow. 2019. Vol. 15, No. 3. Pp. 78-88.
Kaprin A.D., Ivanov S.A., Karyakin O.B., Biryukov V.A., Obukhov A.A., Borysheva N.B., Lepilina O.G., Gumenetskaya Y.V., Kasymov M.R. Experience in the application of high-dose-rate brachytherapy for prostate cancer in monotherapy and in combination with 3D-conformal external beam radiotherapy. //Proceedings of the XIV International Congress of ROOU, 3-4 October 2019, Moscow. 2019. P. 32.
Kaprin A.D., Ivanov S.A., Karyakin O.B., Biryukov V.A., Obukhov A.A., Borysheva N.B., Lepilina O.G., Gumenetskaya Y.V., Kasymov M.R. Salvage high-dose-rate brachytherapy (192Ir) for recurrent prostate cancer. //Proceedings of the XIV International Congress of ROOU, 3-4 October 2019, Moscow. 2019. P. 33.
Kasymov M.R., Chaikov V.S., Zaborsky I.N. Three-year oncological and functional outcomes of laparoscopic prostatectomies at the A.F. Tsyba MRNC. //Proceedings of the XIV International Congress of ROOU, 3-4 October 2019, Moscow. 2019. P. 34.
Troyanov A.V., Gumenetskaya Y.V., Biryukov V.A., Kasymov M.R., Minaeva N.G., Ivanov S.A., Kaprin A.D. Comprehensive chemohormonal-radiation treatment of localized prostate cancer with high or very high risk of progression: first results. //Proceedings of the XIV International Congress of ROOU, October 3-4, 2019, Moscow. 2019. P. 54.
Zaborsky I.N., Ivanov S.A., Karyakin O.B., Safiullin K.N., Kasymov M.R. Assessment of the effectiveness mechanism of the PD-L1 molecular-genetic marker system for predicting bladder cancer and determining its sensitivity to adjuvant and neoadjuvant therapy. //Proceedings of the XIV International Congress of ROOU, October 3-4, 2019, Moscow. 2019. P. 62.
Sergienko S.A., Mikhaylenko D.S., Zaborsky I.N., Martynov M.I., Safiullin K.N., Kuznetsova E.B., Bure I.V., Nemtsova M.V., Alekseev B.Y. Prognostic significance of mutations in FGFR3, PIK3CA, TERT and TP53 genes in non-muscle-invasive bladder cancer. //Proceedings of the XIV International Congress of ROOU, October 3-4 Moscow, 2019
Zaborskii IN, Ivanov SA, Karyakin OB, Safiullin KN. Evaluation of the mechanism of efficiency of PD-L1 molecular genetic marker system for prognosis of bladder cancer and determination of its sensitivity to adjuvant and neoadjuvant therapy. //Mathews journal of cancer science. 2019. P. 111.
Kariakin O.B. Bladder cancer: what’s new in 2018-2019 //Oncourology. Moscow. 2019. Vol. 15, No. 4. P. 113-121.
Alekseev B.Ya., Atduyev V.A., Volkova M.A., Gafonov R.A., Zyryanov A.V., Kaopinsky A.S., Karlov P.A., Kariakin O.B., Matveev V.B., Nosov D.A., Usynin E.A., Popov A.M., Shirokorad V.I. Resolution following the expert council on the treatment of clear cell disseminated metastatic renal cell carcinoma //Oncourology. Moscow. 2019. Vol. 15, No. 2. P. 150-153.
Demianovich A., Sanin D., Martynova V., Borysheva N., Obuhov A., Aminov G., Gulidov I., Mardyntsky Y., Kiseleva M., Ivanov S., Kaprin A. Experience in multicatheter interstitial high-dose-rate breast brachytherapy: dose-volume histogram analysis of the first results //Journal of Contemporary Brachytherapy. 2019. Vol. 11, No. 4. P. 349-355.
Zaborsky I.N., Safiullin K.N., Kariakin O.B., Ivanov S.A., Chaikov V.S., Dementiev I.O., Sidorin A.V., Grishin G.N., Yurchenko A.N. Modern possibilities of endoscopic diagnosis of non-muscle invasive bladder cancer. //Research in Practice and Medicine. 2020. Vol. 7, No. 2. Pp. 129-143.
Troianov A.V., Karyakin O.B., Gumenetskaya Y.V., Biryukov V.A., Chaikov V.S., Zaborsky I.N., Dementyev I.O., Obukhov A.A., Yurchenko A.N., Minaeva N.G., Shchukina E.O., Pirozhenko G.A., Ivanov S.A., Kaprin A.D. Comprehensive chemohormonal-radiation treatment of high and very high-risk prostate cancer without distant metastases: interim results. //Oncourlogists. Proceedings of the XV International Congress of ROU, 30.09-02.10.2020, Moscow. Moscow. 2020. P. 53.
Chaikov V.S., Gumenetskaya Y.V., Karyakin O.B., Biryukov V.A., Nyushko K.M., Dementyev I.O., Troianov A.V., Zaborsky I.N., Yurchenko A.N., Neledov D.V., Minaeva N.G., Shchukina E.O. Five-year results of hormonoradiotherapy for locally advanced prostate cancer with escalation of cumulative focal dose. //Oncourlogy. Proceedings of the XV International Congress of ROU, Moscow. Moscow. 30.09-02.10.2020. P. 54.
Chaikov V.S., Nyushko K.M., Dementiev I.O., Troyanov A.V., Zaborsky I.N., Yurchenko A.N., Neledov D.V., Minaeva E.G., Shchukina E.O. Laparoscopic prostatectomy: surgical and functional outcomes in 200 patients operated on in a single centre. //Oncourology. Proceedings of the XV International Congress of ROOU. 30.09-02.10.2020, Moscow. Moscow. 2020. P. 54-55.
Zaborsky I.N., Safiullin K.N., Ivanov S.A., Nyushko K.M., Chaikov V.S., Troyanov A.V., Dementiev I.O. Evaluation of the molecular-genetic marker PD-L1 for determining the effectiveness of intravesical immunotherapy with the BCG vaccine in patients with high-risk non-muscle-invasive bladder cancer. //Oncourology. Proceedings of the XV International Congress of ROOU. 30.09-02.10.2020, Moscow. Moscow. 2020. P. 60-61.
Safiullin K.N., Zaborsky I.N. High-intensity laser radiation in the treatment of non-muscle-invasive bladder cancer. //Oncourology, Proceedings of the XV International Congress of ROOU, 30.09-02.10.2020, Moscow. Moscow. 2020. P. 74-75
Bolotina L.V., Zaborsky I.N., Safiullin K.N., Gurin E.V., Volozhina L.N., Semenova E.S., Gurchev A.A., Gladkikh O.P., Zhabina A.S., Tarasova A.V. Bladder cancer: treatment after progression. Results of the 2nd retrospective analysis of data on the use of Vinflunine in patients with metastatic urothelial carcinoma in real clinical practice in Russia. //Oncourology. Moscow. 2020. Vol. 16, No. 3. P. 135-142.
Kireeva T.A., Gumenetskaya Yu.V., Biryukov V.A., Makarova K.S., Dzhabrailov S.O., Strikanova I.A. Radiation reactions and complications of combined radiotherapy for prostate cancer. //Radiation and the Organism: Proceedings of the Final Scientific and Practical Conference. Obninsk: A.Tsyb MRRC. Obninsk. 2020. P. 39-40.
Makarova K.S., Gumenetskaya Yu.V., Biryukov V.A., Obukhov A.A., Strikanova I.A. Hypofractionation of the dose in combined radiotherapy in patients with prostate cancer.
Stepanenko V.F., Kolyzhenkov T.V., Bogacheva V.V., Petukhov A.D., Biryukov V.A., Boisheva N.B., Kiseleva M.V., Korotkov V.A., Krikunova L.I., Kulieva G.Z., Zharova E.P., Yaskova E.K., Rukhadze G.A., Ivanov S.A., Shegay P.V., Kaprin A.D. Development and application of radiation-induced stimulated luminescence technologies in oncoradiology and radiation safety: results and prospects. //Radiation and the body: materials of the final scientific-practical conference. Obninsk: A. Tsyb MRRC – branch of the FSBI “National Medical Research Radiological Centre” of the Ministry of healh of the Russian Federation Obninsk. 2020. P. 78-79.